Study on the differences in serum 25-hydroxyvitamin D and heat shock protein 70 levels among female infertility patients with different types of polycystic ovary syndrome
XU Anli
ZHU Li
QIU Yunlin
TONG Yinyin
WANG Shilian
ZHANG Ruopeng
Abstract：Objective To study the differences in serum 25-Hydroxyvitamin D[25(OH)D]and heat shock protein 70(HSP70)levels among female infertility patients with different types of polycystic ovary syndrome(PCOS).Methods A total of 250 female infertility patients who visited the doctors at Department of Reproductive Medicine,the First Affiliated Hospital of Dali University from January 2022 to December 2024 were selected as the research subjects.Among the 250 patients,there were 50 patients with tubal infertility(control group)and 200 patients with infertility due to PCOS(PCOS group).According to the Rotterdam diagnostic and typing criteria for PCOS,the infertile patients with PCOS were classified into PCOS-A type(n=50),PCOS-B type(n=50),PCOS-C type(n=50)and PCOS-D type(n=50).According to different serum 25(OH)D levels,the vitamin D levels of the patients were classified as deficiency(＜20 ng/mL),insufficiency(20-30 ng/mL),and sufficiency(＞30 ng/mL).The levels of serum basic sex hormones,25(OH)D and HSP70 were compared among the groups.Results The levels of 25(OH)D and follicle-stimulating hormone(FSH)in the PCOS group were lower than those in the control group,and the body mass index(BMI)as well as the levels of HSP70,luteinising hormone(LH),testosterone(T)and anti-Müllerian hormone(AMH)in the PCOS group were higher than those in the control group,with statistically significant differences between the two groups(P＜0.05).There was a statistically significant difference in the distribution of 25(OH)D levels between the two groups(P＜0.05).The rate of vitamin D deficiency in the PCOS group was higher.There were no statistically significant differences in the distributions of 25(OH)D levels among the patients with different types of PCOS(P＞0.05).There were statistically significant differences in the levels of LH,FSH,T,AMH and HSP70 among the infertile patients with different types of PCOS(P＜0.05).The LH level of the patients with PCOS-A type was significantly higher than that of the patients with PCOS-B type,PCOS-C type and PCOS-D type(P＜0.05),while the FSH level of the patients with PCOS-A type was significantly lower than that of the patients with PCOS-C type(P＜0.05).The HSP70 levels of the patients with PCOS-A type and PCOS-B type were significantly higher than those of the patients with PCOS-D type(P＜0.05).Conclusion Compared with those in the tubal infertility patients,the levels of serum HSP70,LH,T and AMH in the infertile patients with PCOS are significantly increased,while the levels of 25(OH)D and FSH are significantly decreased in the infertile patients with PCOS.The increase of HSP70 in the infertile patients with PCOS shows significant phenotypic differences,with significantly higher levels in the infertile patients with typical hyperandrogenic phenotypes of PCOS(including PCOS-A type and PCOS-B type)compared with those with non-hyperandrogenic phenotypes of PCOS(PCOS-D type).There are no significant differences in the distributions of vitamin D deficiency among the patients with four phenotypes of PCOS.High expression of HSP70 is associated with hyperandrogenemia features,whereas vitamin D deficiency is a common metabolic alteration in the infertile patients with PCOS patients and is unrelated to specific clinical phenotypes.
Keywords：Vitamin D25-Hydroxyvitamin D[25(OH)D]Heat shock protein 70(HSP70)Polycystic ovary syndrome(PCOS)
Publication Date：2026-01-30
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 36-40 )