Research progress of hyperthermic intraperitoneal chemotherapy combined with multimodal therapy in regulating the microenvironment of gynecological malignant tumors
DUAN Shiqian
YANG Jiang
WEN Shiyu
QIN Xiaomin
Abstract：The global burden of diseases in cervical cancer,endometrial cancer and ovarian cancer continues to increase,and the onset age of patients with these diseases shows a trend of getting younger.As an emerging therapeutic strategy,hyperthermic intraperitoneal chemotherapy(HIPEC)has been proven to significantly improve the prognosis of patients with advanced,recurrent or metastatic gynecological malignant tumors by constructing a synergistic thermochemotherapy system,especially in ovarian cancer patients after interval cytoreductive surgery.Given that the regulation of tumor microenvironment is a key mechanism for HIPEC to exert therapeutic effects,in-depth research on the mechanism is expected to provide the patients with more precise personalized treatment regimens.In this paper,the research progress of HIPEC combined with multimodal therapy in regulating the microenvironment of gynecological malignant tumors is reviewed.
Keywords：Gynecological malignant tumorsHyperthermic intraperitoneal chemotherapy(HIPEC)Tumor microenvironmentPrecision treatmentCombined treatment
Publication Date：2025-12-30
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：5( 1420-1424 )