Research progress in complex immunopathogenesis and multi-target therapy of polymyositis
MA Jingshu
GAO Mengxun
HU Maomao
WANG Miaomiao
MA Feilan
GUO Donggeng
Abstract：Polymyositis(PM)is a rare heterogeneous autoimmune disorder,characterized by symmetrical proximal muscle weakness as the mainly clinical manifestation,which can affect the quality of life and life expectancy of the patients.The etiology and pathogenesis of PM are complex and highly heterogeneous,involving multiple levels and pathways such as genetic susceptibility,environmental triggering factors and the immune system.In this paper,the research progress in complex immunopathogenesis and multi-target therapy of PM is reviewed.
Keywords：Polymyositis(PM)ImmunopathogenesisMulti-target therapyMyositis-specific autoantibodies(MSAs)
Publication Date：2025-12-30
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：5( 1415-1419 )