Precision medicine for IgA nephropathy:frontiers in epidemiology and pathogenesis
ZHOU Ruijia
LIU Hong
Abstract：Immunoglobulin A(IgA)nephropathy(IgAN),also known as Berger's disease,is a glomerular disease characterized by the deposition of IgA or IgA immune complexes in the glomerular mesangial area.At present,IgAN is the most common primary glomerular disease worldwide.The characteristics of IgAN are complex due to differences in region,race,gender and age,suggesting that genetic and environmental factors play key roles in IgAN.In recent years,breakthroughs have been made in the research on the pathogenesis of IgAN in the aspects of immunology and molecular pathological mechanisms.The core link in the development of IgAN is the imbalance in the formation and clearance of the galactose-deficient immunoglobulin A1(Gd-IgA1)immune complex driven by mucosal immune dysregulation,resulting in IgA-specific deposition in the mesangial area and complement activation,which is the result of the interplay of genetic-environmental-immune factors.The hypothesis on anti-mesangial cell autoantibodies proposed in recent years has provided a new perspective for research on the etiology of IgAN.This paper systematically integrates the cutting-edge evidence on the epidemiology and pathogenesis of IgAN,providing a theoretical basis for the individualized treatment of IgAN.
Keywords：Immunoglobulin A(IgA)nephropathy(IgAN)EpidemiologyGalactose-deficient immunoglobulin A1(Gd-IgA1)Autoimmunity
Publication Date：2025-12-30
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：8( 1328-1335 )