Research progress in effects of drugs for general anesthesia on brain development of infants and young children
JIN Hua
SHI Zhaoling
QIN Weifeng
SHI Wenpu
SUN Xude
ZHANG Xiajing
Abstract：With the widespread application of general anesthesia techniques in pediatric patients,the effects of drugs for general anesthesia on their developing brain function have become one of the issues that people pay high attention to.The prolonged and repeated exposures of drugs for general anesthesia to infants and young children during their infancy and early childhood may lead to long-term cognitive and behavioral function impairments,significantly increasing the risk of developing diseases such as learning disabilities and attention deficit disorders.The neurotoxic mechanisms such as apoptosis,mitochondrial dysfunction and oxidative stress caused by early exposure to drugs for general anesthesia may be significant causes of long-term cognitive and behavioral function impairments in infants and young children.In this paper,the research progress in the effects of drugs for general anesthesia on brain development of infants and young children is reviewed.
Keywords：Drugs for general anesthesiaInfants and young childrenBrain developmentCognitive functionNeurotoxic mechanisms
Publication Date：2025-11-30
Online Publishing Date：2025-12-25(First online date of this platform, not the publication date of the document)
Pages：5( 1312-1316 )