The current research status and prospects of fertility preservation in pediatric hematopoietic stem cell transplantation
YANG Jun
QIN Maoquan
WANG Tianyou
Abstract：Pediatric hematopoietic stem cell transplantation(HSCT),as an important means of treating various malignant and non-malignant hematological diseases,has been widely applied in recent years.However,the conditioning protocols before transplantation,such as chemotherapy and radiotherapy,may cause irreversible damage to the gonadal function of the pediatric patients,potentially impacting their future fertility.Therefore,implementing fertility preservation measures is of great significance in pediatric HSCT.At present,relevant researches in this field at home and abroad are gradually increasing,but there are still problems such as non-standard application of technology and ethical disputes.This paper aims to review the latest progress of fertility preservation measures in pediatric HSCT,with an interpretion on Chinese Expert Consensus on Fertility Preservation for Female Patients Undergoing Hematopoietic Stem Cell Transplantation released in 2022,analyzing the current status,ethical challenges encountered,and future development directions of the existing technologies in clinical practice,in order to provide valuable reference and guidance for clinical practice.
Keywords：Pediatric hematopoietic stem cell transplantationFertility preservationOvarian tissue cryopreservationOocyte cryopreservationTesticular tissue cryopreservationExpert consensus
Publication Date：2025-11-30
Online Publishing Date：2025-12-25(First online date of this platform, not the publication date of the document)
Pages：6( 1200-1205 )