Analysis on safety and short-term efficacy of postoperative adjuvant hyperthermic intrathoracic perfusion treatment for patients with stages Ⅲ-Ⅳ thymoma
LIU Rutaiyang
PANG Dazhi
PENG Tao
YAN Jinjin
ZHANG Jitian
SHAO Guangqiang
LIU Zhihai
PENG Hao
TANG Ying
Abstract：Objective To explore the safety and short-term efficacy of postoperative hyperthermic intrathoracic perfusion treatment(HITP)in patients with stagesⅢ-Ⅳthymoma who underwent tumor-reductive surgery to the most extent.Methods A retrospective analysis was conducted on the clinical data of 17 patients with stages Ⅲ-Ⅳ thymoma who were admitted to the University of Hong Kong-Shenzhen Hospital from June 2022 to July 2025.All the patients underwent tumor-reductive surgery to the most extent and received postoperative HITP(with normal saline at 46-48℃for 60 minutes,once every 24 hours with a total of 3-5 treatments).The patients'perioperative complications,adverse reactions and survival outcomes were recorded.The follow-up methods included outpatient re-examination,phone calls and WeChat communication.Results Among the 17 patients,16 patients were completed 3 to 5 times of HITP as planned,while 1 patient was only completed 1 time of HITP.One patient experienced unbearable significant chest tightness after surgery,and the major adverse reactions in the other 16 patients were mild chest tightness and discomfort.No severe complications such as severe arrhythmia,respiratory failure,major bleeding and anastomotic fistula were observed.No obvious impairments of heart,lung,liver and kidney functions occurred.During the follow-up period of 1-38 months,all the patients survived,and thoracic recurrence occurred in 2 patients with stage Ⅳ A thymoma.Conclusion The combined HITP demonstrates good safety and manageable adverse reactions in patients with stages Ⅲ-Ⅳ thymoma who underwent tumor-reductive surgery to the most extent.However,its long-term efficacy still needs further verification through prospective studies with large sample sizes and long-term follow-up.
Keywords：ThymomaHyperthermic intrathoracic perfusion treatment(HITP)Tumor-reductive surgeryShort-term efficacy
Publication Date：2025-10-30
Online Publishing Date：2025-11-13(First online date of this platform, not the publication date of the document)
Pages：5( 1097-1101 )