Study on the value of preoperative albumin-bilirubin grade in predicting patients' clinical prognosis after radical resection of hilar cholangiocarcinoma
QIAN Chunhang
GENG Qin
KANG Qiang
LI Jing
YANG Chen
KE Yang
LI Yuehua
Abstract：Objective To explore the value of preoperative albumin-bilirubin(ALBI)grade in predicting patients' clinical prognosis after radical resection of hilar cholangiocarcinoma(HCCA).Methods The clinical data of 115 patients with HCCA who underwent surgical treatment in the Second Affiliated Hospital of Kunming Medical University from July 2015 to December 2022 were retrospectively analyzed.The ALBI was calculated based on the albumin and bilirubin values of the HCCA patients within 1 week before the operation.According to the ALBI grading system(ALBI ≤-2.60 as grade 1,-2.60＜ALBI ≤-1.39 as grade 2,and ALBI＞-1.39 as grade 3),the HCCA patients were graded,including 4 patients with ALBI grade 1,91 patients with ALBI grade 2 and 20 patients with ALBI grade 3.The survival prognosis of the HCCA patients in the preoperative ALBI grade 1-2 group(Due to the small number of patients with ALBI grade 1,the patients with ALBI grade 1 and those with ALBI grade 2 were combined into one group)and the preoperative ALBI grade 3 group was compared.The factors affecting the survival prognosis of the patients were analyzed by using Cox regression.Results The median disease-free survival(DFS)of the patients in the preoperative ALBI grade 1-2 group and the preoperative ALBI grade 3 group was 23 months and 10 months,respectively,with statistically significant difference in prognosis of DFS between the two groups(P＜0.05),and their median overall survival(OS)was 36 months and 17 months,respectively,with statistically significant difference in prognosis of OS between the two groups(P＜0.05).The results of multivariate Cox regression analysis showed that preoperative ALBI grade 3,vascular carcinoma embolus and American Joint Committee on Cancer(AJCC)stages(TNM stages)Ⅲ and Ⅳ were independent risk factors for DFS in the HCCA patients after operation(P＜0.05),and preoperative ALBI grade 3,AJCC stages(TNM stages)Ⅲ and Ⅳ were independent risk factors for OS in the HCCA patients after operation(P＜0.05).Conclusion Preoperative ALBI grade has predictive value for the prognosis of HCCA patients after radical resection of HCCA.
Keywords：Hilar cholangiocarcinoma(HCCA)Preoperative albumin-bilirubin(ALBI)gradeRadical surgeryPrognosisPrediction
Publication Date：2025-09-30
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：6( 969-974 )