Comparison of efficacy between laparoscopic and laparotomic intention-to-cure radical resections for gallbladder cancer
ZHENG Kai
JIANG Gaiming
LI Jing
KANG Qiang
YANG Chen
KE Yang
LI Yuehua
Abstract：Objective To explore the efficacy between laparoscopic and laparotomic intention-to-cure radical resections for gallbladder cancer,and to provide evidence-based basis for clinical treatment options.Methods A retrospective analysis was conducted on the clinical data of 150 patients who were admitted to the Second Affiliated Hospital of Kunming Medical University and received intention-to-cure radical resection for gallbladder cancer from January 2017 to December 2022.According to the surgical methods,the patients were divided into laparoscopic surgery group(48 patients)and laparotomic surgery group(102 patients).Propensity score matching(PSM)was used to balance the differences in baseline data.A total of 72 patients were successfully matched,including 36 patients in the laparoscopic surgery group and 36 patients in the laparotomic surgery group.The differences in perioperative indicators and survival prognosis were compared between the two groups.The risk factors affecting the survival prognosis of the patients were analyzed by using Cox regression.Results After matching,the baseline data in the two groups were balanced.The laparoscopic surgery group had significantly less intraoperative blood loss and significantly shorter postoperative hospital stay than the laparotomic surgery group(P＜0.05).The results of survival analysis showed that for the gallbladder cancer patients with stage T3 and below,there was no significant difference in overall survival between the laparoscopic surgery group and the laparotomic surgery group(P＞0.05).The results of Cox regression analysis showed that complicating cholecystolithiasis and stage T3 were independent risk factors affecting the GBC patients' survival prognosis[HR(95％CI)=1.70(1.02-2.83),P=0.040;HR(95％CI)=6.07(1.44-25.60),P=0.014].Conclusion In radical cholecystectomy,for the patients with stage T3 and below who have been strictly screened,the efficacy of laparoscopic surgery is comparable to that of laparotomic surgery.However,the conclusion still requires more high-quality evidence-based practice for further verification.
Keywords：Gallbladder cancerLaparoscopePropensity score matching(PSM)EfficacySafety
Publication Date：2025-09-30
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：7( 962-968 )