Advances in local and systemic therapies for recurrent hepatocellular carcinoma
HU Ding
HUANG Jiwei
WANG Haichuan
Abstract：Recurrent hepatocellular carcinoma(rHCC)is a major obstacle affecting the long-term survival of primary hepatocellular carcinoma(HCC)patients after receiving initial treatment for HCC,and their recurrence rate of HCC reaches as high as 70％within 5 years.This paper systematically reviews the latest progress in the field of local and systemic therapies for rHCC.Local therapies include repeat hepatectomy,salvage liver transplantation,radiofrequency ablation,microwave ablation,transarterial chemoembolization,hepatic arterial infusion chemotherapy,transarterial radioembolization as well as newly-developing therapies(such as stereotactic body radiotherapy and proton beam therapy).Systemic therapies include targeted therapy and immunotherapy.These therapies significantly improve the prognosis of patients with rHCC.
Keywords：Recurrent hepatocellular carcinoma(rHCC)Local therapySystemic therapyCombined therapyTargeted therapy
Publication Date：2025-09-30
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：8( 954-961 )