Observation on clinical effectiveness of laparoendoscopic single-site nipple-areola-sparing subcutaneous mastectomy combined with prosthetic implant breast reconstruction in treatment of breast cancer

YE Xian; DENG Runshu; YUAN Yongxian; DENG Dingmei; WEN Runyao; HE Guangning

doi:10.3969/j.issn.1674-3806.2025.06.15

Abstract：Objective To observe the clinical effectiveness of laparoendoscopic single-site nipple-areola-sparing subcutaneous mastectomy(NSM)combined with prosthetic implant breast reconstruction in treatment of breast cancer.Methods The clinical data of 101 patients with breast cancer who were admitted to the Tenth Affiliated Hospital,Southern Medical University(Dongguan People's Hospital)from August 2020 to August 2023 were retrospectively analyzed.According to different surgical methods received by the patients,they were divided into observation group(receiving laparoendoscopic single-site NSM combined with prosthetic implant breast reconstruction,39 cases)and control group(receiving traditional open surgery combined with prosthetic implant breast reconstruction,62 cases).The perioperative indicators,serum tumor marker levels,prognosis and cosmetic outcome of the breast were compared between the two groups.Results The operative duration,surgical incision length and length of stay in hospital in the observation group were shorter than those in the control group,and the number of incisions and intraoperative blood loss in the observation group were less than those in the control group,with statistically significant differences between the two groups(P＜0.05).There was no statistically significant difference in the incidence of complications between the two groups(P＞0.05).There were no statistically significant differences in the levels of serum tumor markers between the two groups before and after operation(P＞0.05).As of October 2024,no local recurrence occurred in both groups.In the control group,2 patients had distant tumor metastasis,including 1 case of supraclavicular lymph node metastasis and 1 case of bone metastasis.No distant tumor metastasis occurred in the observation group.There were no death patients in both groups during the follow-up period.The proportion of excellent and good Harris Scale scores in the observation group was higher than that in the control group,and the overall situation of cosmetic outcome of the breast in the observation group was better than that in the control group,with statistically significant difference between the two groups(P＜0.05).Conclusion Laparoendoscopic single-site NSM combined with prosthetic implant breast reconstruction is minimally invasive,with good prognosis and favorable cosmetic outcome of the breast after operation,and is recommended for clinical use in treatment of breast cancer.