Interpretation on key points of updated domestic and foreign guidelines for premature ovarian insufficiency
PU Danhua
WU Jie
Abstract：Premature ovarian insufficiency(POI)is a clinical syndrome characterized by ovarian dysfunction in women before the age of 40 years.It can manifest as abnormal menstruation,infertility and low estrogen symptoms.Moreover,it increases the occurrence risk of chronic diseases such as cardiovascular diseases and osteoporosis,seriously affecting women's reproductive health and quality of life.In recent years,the incidence of POI has been on the rise.The etiology of POI is complex and involves multiple mechanisms such as genetics,autoimmunity,iatrogenic injury and idiopathic factors.Although hormone replacement therapy can alleviate the symptoms of POI and improve the patients' quality of life,there are still no effective treatment strategies for the recovery of the patients' fertility.Based on the latest papers Evidence-Based Guideline:Premature Ovarian Insufficiency published by Human Reproduction Open in 2024 and Chinese Expert Consensus on Clinical Diagnosis and Treatment of Premature Ovarian Insufficiency(2023 Edition),combined with new research progress,this paper analyzes the etiology,diagnosis,treatment strategies and long-term management of POI,with the aim of providing guidance for the early diagnosis and treatment of POI in clinical practice.
Keywords：Premature ovarian insufficiency(POI)Ovarian functionHormone replacement therapyEvidence-based guidelineAdvances in diagnosis and treatmentInterpretation
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 589-593 )