Clinical efficacy and safety of allylestrenol in treatment of abnormal uterine bleeding due to ovulatory dysfunction in childbearing age
JIA Qiucheng
WEI Weiwei
CHEN Jiming
YU Yi
CHEN Wanying
LIU Chi
CAO Ying
XUE Wenpeng
XING Tingwei
LIU Junling
MIN Yifei
Abstract：Objective To explore the clinical efficacy and safety of allylestrenol in treatment of abnormal uterine bleeding due to ovulatory dysfunction in childbearing age.Methods The clinical data of 207 patients with abnormal uterine bleeding due to ovulatory dysfunction in childbearing age who were admitted to Department of Gynecology,the Third Affiliated Hospital of Nanjing Medical University(Changzhou No.2 People's Hospital)from January 2023 to November 2024 were retrospectively analyzed.The patients were divided into observation group(90 cases)and control group(117 cases)according to different treatment methods.The observation group began to take 5 mg of allylestrenol orally on the 15th day of menstruation,twice a day,and continued oral administration for 14 days as 1 course of the treatment.The control group began to take 10 mg of dydrogesterone orally on the 15th day of menstruation,twice a day,and continued oral administration for 14 days as one course of the treatment.Both groups were treated with medication for three consecutive courses.The menstrual volume[Pictorial Blood Loss Assessment Chart(PBAC)score was used for assessment],endometrial thickness and hemoglobin level were compared between the two groups before and after treatment.The clinical efficacy,symptom relief time,symptom disappearance time and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate was 93.33％in the observation group and 91.45％in the control group.There was no statistically significant difference in the total clinical effective rate between the two groups(P＞0.05).After the treatments,the PBAC scores and endometrial thickness in both groups decreased significantly compared with those before the treatments(P＜0.05),and the hemoglobin levels in both groups increased significantly compared with those before the treatments(P＜0.05),but there were no statistically significant differences between the two groups(P＞0.05).The symptom relief time and symptom disappearance time in the observation group was faster than that in the control group,with statistically significant difference between the two groups(P＜0.05).The incidence of adverse reactions in the observation group was 8.89％(8/90),and that in the control group was 5.13％(6/117).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Allylestrenol and dydrogesterone have similar efficacy in treatment of abnormal uterine bleeding due to ovulatory dysfunction in childbearing age,and both have good safety in short-course clinical medications.
Keywords：AllylestrenolDydrogesteroneChildbearing ageAbnormal uterine bleeding due to ovulatory dysfunction
Publication Date：2025-05-30
Pages：5( 508-512 )