Comparison of predictive efficacy of three recent infection testing algorithms for recent infections in newly reported HIV-1 infected individuals
YANG Hong
ZHANG Ying
WANG Nan
WAN Xiaoyu
XIAO Li
ZHOU Chang
LIANG Shu
Abstract：Objective To compare the predictive efficacy of three recent infection testing algorithms(RITAs)for recent infections in newly reported human immunodeficiency virus(HIV)-1 infected individuals in a city of Sichuan Province.Methods The data of newly reported HIV-1 infected individuals in a city of Sichuan Province from 2022 to 2024 were collected.Based on the different baselines of the samples,the combinations of indicators were divided into three RITAs:no antiviral treatment+limiting antigen avidity enzyme immunoassay(LAg-EIA)+CD4+T-lymphocyte count(RITA1);no antiviral treatment+LAg-EIA+baseline viral load(RITA2);no antiviral treatment+LAg-EIA+CD4+T-lymphocyte count+baseline viral load(RITA3).Taking the prediction of recent infections by infection time as the reference strategy in this study,the coincidence rates of the three RITAs were calculated respectively.The predictive efficacy of different strategies was compared by using x2 test and receiver operating characteristic(ROC)curve analysis.Results A total of 349 patients with HIV-1 infection were included in this study.These HIV-1 infection patients were infected mainly through heterosexual sexual transmission(95.13％),aged 55 years and above(76.79％),and male(66.19％).The first CD4+T-lymphocyte count was less than 200 cells/μL in 150 cases(42.98％).The coincidence rates of RITA1,RITA2 and RITA3 were 71.92％,69.63％and 71.92％,respectively.Based on the comprehensive results of x2 test and ROC curve analysis,RITA1 and RITA2 showed no significant difference in the prediction of recent infections of HIV-1 compared with the reference strategy,with certain application value.The specificity of RITA2 was the highest,which was 0.762,and the area under its ROC curve was 0.600(95％CI:0.525-0.674).Conclusion Incorporating immunological and virological indicators into existing RITAs for HIV-1 has certain predictive significance for recent infections in newly reported HIV-1 infected individuals.Each region should select appropriate predictive strategies based on the local epidemic situation and the baseline test data of the HIV-1 infected individuals.
Keywords：Human immunodeficiency virus-1(HIV-1)Recent infection testing algorithms(RITAs)Limiting antigen avidity enzyme immunoassay(LAg-EIA)Baseline viral loadCD4+T-lymphocyte countHuman immunodeficiency virus infection
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 378-383 )