A survey on current status of vaccination in immunization program for HIV-infected children in Guangxi

TANG Shuai; LIU Jing; LIU Xuanhua; WU Xiuling; WEI Jianan; ZHU Qiuying

doi:10.3969/j.issn.1674-3806.2025.04.04

Abstract：Objective To survey the current status of vaccination in immunization program for HIV-infected children in Guangxi.Methods The case information of 37 HIV-infected children born between January 1,2017 and December 31,2019 and their parents who were registered in the HIV/AIDS Comprehensive Response Information Management System and survived before December 31,2022 and whose current addresses were Guangxi were collected.The vaccination information of the HIV-infected children was obtained from Guangxi Immunization Information System,and the records of the HIV-infected children'adverse events following immunization(AEFI)were searched from suspected AEFI monitoring system.The comprehensive data were analyzed statistically to understand the vaccination status of the HIV-infected children in the immunization program.Results Among the 37 HIV-infected children,there were 19 males and 18 females.The median age at which HIV was confirmed positive was 19 months.The main pathway of infection was mother-to-child transmission(35 cases,accounting for 94.59％).Thirty cases were undergoing antiviral treatment.The mothers were infected with HIV at the time of delivery(including pre-pregnancy,pregnancy,perinatal confirmed positive)in 20 cases,and the mothers were found to be HIV-positive in 17 cases after their deliveries.The immunization coverage rate of hepatitis B vaccine in the 37 HIV-infected children was 94.59％,and their immunization coverage rates of acellular diphtheria-pertussis-tetanus vaccine,group A meningococcal polysaccharide vaccine,group A+group C meningococcal polysaccharide conjugate vaccine were 75.68％.Their immunization coverage rate of live attenuated measles-containing vaccines was 65.71％.Among the 37 HIV-infected children,33 children received 162 doses of live attenuated vaccine.However,no abnormal reactions associated with the vaccinations had been reported.Conclusion Mother-to-child transmission is still the main pathway of HIV infection in children in Guangxi.The age of children at diagnosis of HIV infection shows a descending trend.Most HIV-infected children have a low vaccination coverage rate in the immunization program.Therefore,it is necessary to strengthen the training on the vaccination knowledge of HIV-infected children and explore more effective vaccination strategies to provide timely vaccine protection for HIV-infected children.