Analysis on therapeutic effects of M1 high-frequency combined with SMA low-frequency rTMS assisting with drug in treatment of elderly Parkinson's disease based on neurotransmitter and CT cerebral blood flow perfusion and their mechanisms
ZHANG Ruijuan
HE Lei
Abstract：Objective To analyze the therapeutic effects of primary motor cortex(M1)high-frequency combined with supplementary motor area(SMA)low-frequency repetitive transcranial magnetic stimulation(rTMS)assisting with drug in treatment of elderly Parkinson's disease based on neurotransmitter and computed tomography(CT)cerebral blood flow perfusion and their mechanisms.Methods One hundred and six patients with elderly Parkinson's disease who were admitted to Yan'an University Xianyang Hospital from September 2021 to June 2023 were recruited and divided into observation group and control group by random number table method,with 53 cases in each group.Both groups were given pramipexole tablets,and on this basis,the control group was given sham stimulation+memantine,while the observation group was given rTMS+memantine.Both groups were treated for 4 weeks.The Unified Parkinson's Disease Rating Scale(UPDRS)scores,Mini-Mental State Examination(MMSE)scores,Hamilton Rating Scale for Anxiety(HAMA)scores,Hamilton Rating Scale for Depression(HAMD)scores,P300 amplitude and latency,neurotransmitter indicators[dopamine,5-hydroxytryptamine,glutamic acid and gamma-aminobutyric acid(GABA)],cerebral blood flow perfusion and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the UPDRS-Ⅱscores,UPDRS-Ⅲ scores,UPDRS total scores,HAMA scores,HAMD scores and P300 latency in the observation group were lower than those in the control group,and the MMSE scores,P300 amplitude,dopamine,5-hydroxytryptamine,glutamic acid,GABA,and the levels of cerebral blood flow perfusion in the temporal lobe,parietal lobe and frontal lobe in the observation group were higher than those in the control group,with statistically significant differences between the two groups(P＜0.05).Conclusion M1 high-frequency combined with SMA low-frequency rTMS assisting with drug can effectively improve the motor and non-motor symptoms in treatment of the patients with elderly Parkinson's disease,regulate the levels of neurotransmitters,increase cerebral blood flow perfusion,and has good safety.
Keywords：Repetitive transcranial magnetic stimulation(rTMS)MemantineOld ageParkinson's diseaseNeurotransmitterCerebral blood flow perfusion
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 292-297 )