A study on effects of allergic enteritis on the risk of functional gastrointestinal disorders in infants and young children

LI Jun; XU Jizhi; HUANG Tengfei; CHEN Lingling; HUANG Yan; GONG Xiaohui

doi:10.3969/j.issn.1674-3806.2025.03.03

Abstract：Objective To study the effects of allergic enteritis on the risk of functional gastrointestinal disorders(FGIDs)in infants and young children.Methods A total of 80 pediatric patients who were diagnosed with allergic enteritis in Changsha Hospital for Maternal and Child Health Care from January 2019 to December 2019 were included as allergic enteritis group,and 80 subjects who were brothers and sisters of the pediatric patients in the allergic enteritis group under 4 years old without a history of milk allergy or were treated in Changsha Hospital for Maternal and Child Health Care due to minor trauma during the same period were included as the control group.The parents of the subjects in the allergic enteritis group and the control group were followed up by telephone every 12 months until the subjects reached the age of 4 years.The immunoglobulin E(IgE)antibody titers of common foods(milk,soybean,rice,wheat and egg)and fecal calprotectin level were detected in all the pediatric patients with allergic enteritis within 1 week before endoscopy by using enzyme-linked immunosorbent assay.The results of endoscopy and pathological examination were recorded.Results Among the 80 pediatric patients with allergic enteritis,12 pediatric patients(15.00％)had FGIDs,while only 4 subjects(5.00％)in the 80 subjects of the control group had FGIDs(x2=2.108,P=0.035).After adjusting for age and gender,multivariate logistic regression analysis showed that the odds ratio(OR)(95％ CI)of FGIDs in the allergic enteritis group was 4.39(1.03-18.68).FGIDs were significantly correlated with iron deficiency anemia,duration of hematochezia and age of onset of allergic enteritis(P＜0.05).Multivariate logistic regression analysis showed that longer duration of hematochezia was an independent risk factor for the occurrence of FGIDs[OR(95％ CI)=3.14(1.72-5.74)].Conclusion Allergic enteritis is a risk factor for the development of FGIDs in infants and young children.Longer duration of hematochezia is an independent risk factor for the occurrence of FGIDs.