Meta-analysis of the effects of continuous glucose monitoring on blood glucose management-related indicators in adult patients with type 1 diabetes mellitus
CHENG Shuang
WANG Li
CHEN Lingxue
FU Adan
YI Lan
WANG Juan
Abstract：Objective To systematically evaluate the effects of continuous glucose monitoring(CGM)on blood glucose management-related indicators in adult patients with type 1 diabetes mellitus(T1DM)by using meta-analysis.Methods Randomized controlled trials(RCTs)involving CGM intervention in adult patients with T1DM were searched by computer in the databases of PubMed,Embase,Web of Science,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform and VIP.The publication time of the searched papers was from the establishment of each database until May 2024.Data analysis was performed using RevMan 5.4 and STATA 17.0 statistical softwares.Results A total of 11 papers were included,with a total sample size of 1 319 cases.The results of meta-analysis showed that the level of glycosylated hemoglobin A1c(HbA1c)in the trial group was lower than that in the control group[MD(95％CI)=-0.18(-0.34--0.02),P=0.03].The results of subgroup analysis showed that there were no significant differences in HbA1c levels in patients with different CGM types and baseline HbA1c levels after intervention(P＞0.05),and the HbA1c level in patients with intervention duration ≥24 weeks was lower than that in patients with intervention duration＜24 weeks.Time in range(TIR)in the trial group was higher than that in control group[MD(95％CI)=6.33(3.29-9.37),P＜0.01].Compared with the control group,CGM could significantly improve the relevant indicators of CGM in adult patients with T1DM,including time below range(TBR),time above range(TAR),coefficient of variation(CV)of glucose,standard deviation(SD)of glucose,low blood glucose index(LBGI),and mean amplitude of glycemic excursion(MAGE)(P＜0.01).There were no significant differences(P＞0.05)in Diabetes Treatment Satisfaction Questionnaire(DTSQ)scores[MD(95％CI)=0.83(-2.44-4.10)],Gold scores[MD(95％CI)=-0.36(-0.77-0.04)],Clarke scores[MD(95％CI)=-0.16(-0.48-0.16)]and the scores of Hypoglycemia Fear Survey-Worry Scale(HFS-WS)[MD(95％CI)=0.34(-4.59-5.27)]between the two groups(P＞0.05).Conclusion CGM can improve HbA1c level and CGM-related indicators in adult patients with T1 DM.CGM is worthy of clinical promotion.
Keywords：Continuous glucose monitoring(CGM)Type 1 diabetes mellitus(T1DM)AdultGlycosylated hemoglobin A1c(HbA1c)Time in range(TIR)
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 217-225 )