Chronic obstructive pulmonary disease and gut-lung microbiota interactions:microbiome-based targeted treatment strategies
FENG Qiantong
LI Aimin
Abstract：Chronic obstructive pulmonary disease(COPD)is a common chronic airway disease with high prevalence and heavy disease burden.With the application of metagenome detection technology,it has been found that the lungs contain low-biomass microbiota,and gut microbiota and lung microbiota have a potential connection through the"gut-lung axis",and jointly participate in the development of COPD.Compared with healthy individuals,COPD patients have abnormal composition and function of lung microbiota and gut microbiota.Based on COPD and gut-lung microbiota interactions,the prevention and treatment of COPD by intervening the gut-lung microbiota have become a new therapeutic direction.In this paper,the distribution characteristics of gut-lung microbiota in COPD patients and the research progress of the mechanism of COPD and gut-lung microbiota interactions are summarized,providing new ideas for clinical diagnosis,treatment and research of COPD.
Keywords：Chronic obstructive pulmonary disease(COPD)Lung microbiotaGut microbiotaGut-lung axis
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 131-135 )