The role of STIM1/ORAI1 signaling pathway in pathogenesis of respiratory diseases
LIANG Jieping
PENG Gongyong
Abstract：Stromal interaction molecule 1(STIM1),a single transmembrane protein located in the endoplasmic reticulum,dynamically senses the changes in intracellular calcium concentration and then transmits calcium signals to OR AI calcium release-activated calcium modulator 1(OR AI1)on the cell membrane,inducing downstream calcium signaling and mediating cellular calcium influx,thereby participating in various physiological functions such as cell proliferation and migration,immune cell activation,gene transcription,etc.The STIM1/ORAI1 signaling pathway plays a key regulatory role in a variety of respiratory diseases,including pulmonary hypertension,bronchial asthma,chronic obstructive pulmonary disease,acute lung injury/acute respiratory distress syndrome,and idiopathic pulmonary fibrosis.In this paper,the latest research progress on the role and mechanism of the STIM1/OAI1 signaling pathway in respiratory diseases is reviewed,with the aim of providing more ideas for the studies on the related diseases and finding possible new research targets for effective clinical diagnosis and treatment.
Keywords：Stromal interaction molecule 1(STIM1)ORAI calcium release-activated calcium modulator 1(ORAI1)Pulmonary hypertensionBronchial asthmaChronic obstructive pulmonary disease
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 18-23 )