Diagnostic value of the combined detection of fractional exhaled nitric oxide and small airway function indicators for cough-variant asthma
LU Jinhua
CHEN Ru
LU Jingchan
LU Ailing
LIAO Xiaoling
HU Guoping
HUANG Luying
Abstract：Objective To explore the diagnostic value of the combined detection of fractional exhaled nitric oxide(FeNO)and small airway function indicators for cough-variant asthma(CVA).Methods A total of 140 patients with chronic cough who visited the outpatient Department of Respiratory and Critical Care Medicine of the People's Hospital of Guangxi Zhuang Autonomous Region from March 2023 to February 2024 were selected as the study subjects.According to the patients'diagnostic results,they were divided into CVA group(43 cases)and non-CVA group(97 cases).The baseline data,FeNO levels,and small airway function were compared between the two groups,and the diagnostic efficacy of the combined detection of FeNO and small airway function indicators for CVA were analyzed.Results The detected FeNO at a 50 mL/s flow rate(FeNO50)(53.00 ppb vs 19.00 ppb),the detected FeNO at a 200 mL/s flow rate(FeNO200)(19.00 ppb vs 8.00 ppb)and the level of alveolar nitric oxide(CaNO)(5.20 ppb vs 3.30 ppb)in the CVA group were higher than those in the non-CVA group,and the differences were statistically significant(P＜0.05).In the CVA group,the FeNO50 levels in the patients complicated with small airway dysfunction were significantly higher than those in the patients without small airway dysfunction(64.50 ppb vs 26.00 ppb,P＜0.05).The results of receiver operating characteristic(ROC)curve analysis showed that FeNO combined with small airway function indicators,maximal mid-expiratory flow(MMEF)and maximum expiratory flow at 25％of vital capacity(MEF25％)had certain diagnostic value for CVA(P＜0.05),and FeNO50 combined with MMEF had better diagnostic value for CVA[area under the curve(AUC)(95％CI)=0.79(0.70,0.87)].Conclusion The levels of FeNO in CVA patients are significantly higher than those in non-CVA patients,and the combined detection of FeNO and small airway function indicators has relatively high diagnostic value for CVA.
Keywords：Cough-variant asthma(CVA)Fractional exhaled nitric oxide(FeNO)Small airway functionDiagnostic value
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 12-17 )