A study on B7-H3 expression in small-cell lung cancer and its correlation with the small-cell lung cancer patients'prognosis

LI Xi; LI Hongxia; LIN Haifeng; WANG Shouzheng; ZHANG Quan; LYU Jialin; LI Jie; ZHENG Hua; HU Ying

doi:10.3969/j.issn.1674-3806.2024.12.07

Abstract：Objective To explore the B7-H3 expression level in small-cell lung cancer(SCLC)and its correlation with the small-cell lung cancer patients'prognosis.Methods Thirty-four SCLC tissue specimens surgically resected in Beijing Chest Hospital,Capital Medical University from January 2010 to July 2019 were collected,and the medical records and follow-up data of the patients from whom the specimens were obtained were collected.The expression of B7-H3 in the SCLC tissues was detected by using immunohistochemical method,and the correlation between the expression level of B7-H3 in the SCLC tissues and the patients'clinical characteristics was analyzed.Results There were 14 patients(41.18％)with high expression of B7-H3 and 20 patients(58.82％)with low expression of B7-H3.The expression of B7-H3 was positive in 26 cases(76.47％)and negative in 8 cases(23.53％).The proportion of lymph node metastasis and the number of lymph node metastasis in the high B7-H3 expression group were higher than those in the low B7-H3 expression group,and the differences were statistically significant(P＜0.05).However,there were no statistically significant differences in gender,age and smoking ratio between the two groups(P＞0.05).Expression of B7-H3 was consistent with score of micro vessel density(MVD)(Kappa=0.339,P=0.048).The MVD scores of the high B7-H3 expression group were higher than those of the low B7-H3 expression group,and the differences were statistically significant(t=3.784,P=0.001).The median overall survival(OS)of the high B7-H3 expression group was shorter than that of the low B7-H3 expression group(13.8 months vs 23.5 months),and the difference in survival prognosis between the two groups was statistically significant(log-rank test:x2=3.873,P=0.049).Conclusion B7-H3 is expressed to varying degrees in SCLC tissues,and high expression of B7-H3 is associated with lymph node metastasis and poor prognosis,which may become a potential target for treatment of SCLC.