A preliminary study on the changes in peripheral blood circulating tumor cells before and after percutaneous transthoracic needle biopsy for lung tumors
XUE Hanjiang
ZHANG Yi
LU Gaojun
QIAN Kun
Abstract：Objective To explore whether puncture can cause tumor cells to enter the bloodstream by comparing the changes in peripheral blood circulating tumor cells(CTCs)before and after percutaneous transthoracic needle biopsy for lung tumors.Methods A total of 46 patients with suspected lung cancer who were admitted to Xuanwu Hospital Capital Medical University from December 2019 to December 2023 were recruited,all of whom receiving percutaneous transthoracic needle biopsy.The patients received CTCs testing(immunomagnetic bead-based negative enrichment+targeted polymerase chain reaction)before and after puncture,and the changes in CTCs before and after puncture were compared.Results In all the enrolled patients,their levels of CTCs were significantly increased after puncture compared with those before puncture(P＜0.05).In the benign tumor group,there were no significant changes in CTCs levels before and after puncture in 11 patients(P＞0.05),while in the malignant tumor group,35 patients had significant increases in CTCs levels after puncture compared with those before puncture(P＜0.05),and in the malignant tumor group,there were no significant changes in CTCs levels before and after puncture in 24 patients of the stage Ⅰ-Ⅲ non-small-cell lung cancer and limited-stage small-cell lung cancer group(P＞0.05),while CTCs levels after puncture in 11 patients of the stage Ⅳ non-small-cell lung cancer and extensive-stage small-cell lung cancer group were significantly increased compared with those before puncture(P＜0.05).Conclusion Percutaneous transthoracic needle biopsy can cause the increased levels of CTCs in patients with stage Ⅳ non-small-cell lung cancer and extensive-stage small-cell lung cancer,but has no significant effect on patients with stage Ⅰ-Ⅲ non-small-cell lung cancer and limited-stage small-cell lung cancer.
Keywords：Lung cancerBenign tumorCirculating tumor cells(CTCs)Percutaneous transthoracic needle biopsyTumor staging
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1347-1351 )