Clinical efficacy of Shenqi Qiangjing Decoction in treating oligoasthenozoospermia and its effect on in vitro fertilization outcomes
CHEN Qigui
LI Dawen
BIN Bin
LU Haiwang
PANG Taisen
Abstract：Objective To explore the clinical efficacy of Shenqi Qiangjing Decoction in treating oligoastheno-zoospermia patients and its effect on in vitro fertilization(IVF)outcomes.Methods A total of 209 patients with oli-goasthenozoospermia who were admitted to the People's Hospital of Guangxi Zhuang Autonomous Region and the First Affiliated Hospital of Guangxi University of Chinese Medicine from October 2020 to December 2022 were recruited.According to the patients'treatment intentions,they were divided into observation group(receiving Shenqi Qiangjing Decoction treatment,108 cases)and control group(receiving L-carnitine treatment,101 cases).After 3 months of treatment,IVF-assisted pregnancy was performed on all the patients.The semen quality and IVF outcomes were compared between the two groups.Results After treatment,sperm DNA fragmentation index(DFI)was significantly decreased in both groups(P＜0.05),and the sperm DFI in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no statistical significance in sperm acrosome integrity rate in the control group before and after treatment(P＞0.05),and sperm acrosome integrity rate in the observation group after treatment was significantly higher than that before treatment(P＜0.05),and the observation group had higher sperm acrosome integrity rate than the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in the sperm progressive motility rate,sperm concentration,total sperm count and normal sperm morphology rate between the two groups after treatment(P＞0.05).The fertilization rate and excellent embryo rate in the observation group were significantly higher than those in the control group(P＜0.05),and there were no significant differences in cleavage rate and clinical pregnancy rate between the two groups(P＞0.05).Conclusion Shenqi Qiangjing Decoction can improve the semen quality of the patients with oligoasthenozoospermia and optimize the IVF outcomes,and improve some indicators more effectively than L-carnitine.
Keywords：Shenqi Qiangjing DecoctionL-carnitineOligoasthenozoospermiaSemen qualityIn vitro fertilization(IVF)outcomes
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1164-1168 )