Exploration on the influence of early blood glucose indicators on survival prognosis of sepsis patients in intensive care unit

ZUO Yanyan; LI Yunwei

doi:10.3969/j.issn.1674-3806.2024.10.15

Abstract：Objective To explore the influence of early blood glucose indicators on survival prognosis of sepsis patients in intensive care unit(ICU).Methods The clinical data of 251 patients with sepsis who were admitted to the ICU of Fourth People's Hospital of Langfang from January 2018 to January 2024 were retrospectively analyzed.According to the patients'survival prognosis,they were divided into survival group(n=165)and death group(n=86).The general clinical data,treatment-related indicators and blood glucose indicators were compared between the two groups.The influence of blood glucose indicators on survival prognosis of the patients was analyzed by using multivariate logistic regression.Results Compared with the survival group,the death group had older age,higher Acute Physiology and Chronic Health Evaluation(APACHE)Ⅱ scores,higher Sequential Organ Failure Assessment(SOFA)scores,more failing organs,higher proportion of patients receiving drugs for raising blood pressure and proportion of patients receiving renal replacement therapy,longer mechanical ventilation time,and greater coefficient of variation(CV)of blood glucose values and stress hyperglycemia ratio(SHR),and the differences were statistically significant(P＜0.05).After adjusting for general clinical data,disease severity and treatment-related indicators,the results of multivariate logistic analysis showed that higher SHR level was a risk factor of death for sepsis patients in ICU(P＜0.05),while CV of blood glucose values had no significant effect on prognosis of sepsis patients in ICU(P＞0.05).Conclusion Higher SHR level is a risk factor of death for sepsis patients in ICU,which is worthy of clinicians'attention.