Evaluation on the clinical application effect of indocyanine green,blue dye and dual-tracer method in sentinel lymph node biopsy under fluorescence endoscope for breast cancer
ZHU Di
XU Xirui
LUO Yunfeng
HE Linyun
ZHU Yanwen
LIAO Yue
ZHANG Pusheng
Abstract：Objective To evaluate the clinical application effect of indocyanine green(ICG),blue dye and dual-tracer method in sentinel lymph node biopsy(SLNB)under fluorescence endoscope for breast cancer.Methods The clinical data of 166 patients with breast cancer who underwent SLNB under fluorescence endoscope by using ICG combined with blue dye dual-tracer method in Department of Breast Surgery,General Surgery Center,Zhujiang Hospital of Southern Medical University from April 2021 to August 2022 were retrospectively analyzed.The development of sentinel lymph node(SLN)and the development of metastatic SLN were compared in endoscopic fluorescence mode,high-definition white light mode,and fluorescence+white light dual-tracer mode.The detectable rates and the detectable number of SLN and metastatic SLN in the three modes were compared,and the tracer performance under endoscope in the three methods were analyzed.Results A total of 610 pieces of SLN were detected in the 166 patients,of whom 48 patients were detected with SLN metastasis,and endoscopic axillary lymph node dissection was performed on them,and a total of 95 pieces of metastatic SLN were detected.The detectable rate of SLN in the dual-tracer method group(98.19％)was significantly higher than that in the blue dye group(82.53％)(P＜0.05),but there was no significant difference in the detectable rate of SLN between the dual-tracer method group(98.19％)and the ICG group(94.58％)(P＞0.05).The number of SLN detected in the dual-tracer method group[(3.52±1.72)pieces]was significantly higher than that detected in the blue dye group[(1.95±1.68)pieces](P＜0.05),but there was no significant difference in the number of SLN detected between the dual-tracer method group[(3.52±1.72)pieces]and the ICG group[(3.36±1.82)pieces](P＞0.05).Conclusion The use of ICG combined with blue dye dual-tracer method in SLNB under fluorescence endo-scope has higher detectable rate of SLN and more numbers of lymph nodes detected.
Keywords：Breast cancerSentinel lymph node biopsy(SLNB)Indocyanine greenFluorescence endoscope
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1092-1097 )