Effect of warming acupuncture combined with intrauterine perfusion of platelet-rich plasma on the outcome of freeze-thaw embryo transfer in patients with thin endometrium of kidney deficiency and blood stasis type
LIN Chunlian
LIU Yanmei
ZHANG Zhao
WU Hongbo
Abstract：Objective To explore the effect of warming acupuncture combined with intrauterine perfusion of platelet-rich plasma(PRP)on the outcome of freeze-thaw embryo transfer in patients with thin endometrium of kidney deficiency and blood stasis type.Methods One hundred and fifty-four patients with thin endometrium of kidney deficiency and blood stasis type who underwent in vitro fertilization and embryo transfer(IVF-ET)in the Reproductive Medicine Center of Qinzhou Maternal and Child Health Hospital from January 2020 to December 2022 were recruited.According to the patients'treatment intentions,they were divided into group A(27 cases,receiving hormone replacement cycle),group B(43 cases,receiving hormone replacement cycle+warming acupuncture treatment),group C(48 cases,receiving hormone replacement cycle+intrauterine perfusion of PRP treatment)and group D(36 cases,receiving hormone replacement cycle+warming acupuncture+intrauterine perfusion of PRP treatment).On the third day after administering progesterone to transform the endometrium,1 to 2 high-quality cleavage stage embryos were transplanted.The endometrial thickness on the day when progesterone was administered to transform the endometrium,clinical pregnancy rate,biochemical preg-nancy rate and early abortion rate were compared among the four groups.Results After treatment,the endometrial thickness in group B,group C and group D on the day when progesterone was administered to transform the endometrium increased compared with those in the previous cycle,and the differences were statistically significant(P＜0.05),and the endometrial thickness in group B,group C and group D on the day when progesterone was administered to trans-form the endometrium was significantly greater than that in group A(P＜0.05).However,there was no statistically sig-nificant difference among group B,group C and group D(P＞0.05).There was no statistically significant difference in the number of transplanted embryos among the four groups.There were statistically significant differences in the clinical pregnancy rate and biochemical pregnancy rate among the four groups(P＜0.05),and the clinical pregnancy rate and biochemical pregnancy rate in group D were the highest,which were 44.44％and 61.11％,respectively.There was no significant difference in the early abortion rate among the four groups(P＞0.05).Conclusion Warming acupuncture combined with intrauterine perfusion of PRP helps to improve the endometrial thickness and the outcome of freeze-thaw embryo transfer in patients with thin endometrium of kidney deficiency and blood stasis type.
Keywords：Platelet-rich plasma(PRP)Warming acupunctureFreeze-thaw embryo transferThin endometriumKidney deficiency and blood stasis typePregnancy outcome
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1032-1036 )