Observation on the therapeutic effect of surgical excision combined with limbal stem cell transplantation on treatment of pterygium
WU Qin
YANG Chunlin
LU Yaoyao
CAO Donglei
Abstract：Objective To observe the therapeutic effect of surgical excision combined with limbal stem cell transplantation on treatment of pterygium.Methods A total of 180 patients with pterygium who were admitted to Qidong Hospital of TCM from January 2020 to December 2022 were recruited and divided into the Ologen collagen matrix im-plantation group(receiving surgical excision combined with Ologen collagen matrix implantation treatment,145 eyes,90 cases)and the limbal stem cell transplantation group(receiving surgical excision combined with limbal stem cell transplantation treatment,147 eyes,90 cases)by using random number table method.The postoperative refractive status,tear film function,comfort level,wound healing time,clinical efficacy and recurrence were compared between the two groups.Results After surgery,the uncorrected visual acuity(UCVA)and tear break-up time(BUT)showed an increasing trend in both groups,while corneal astigmatism(CA)showed a decreasing trend,and the differences in the changing amplitudes between the two groups were statistically significant(P＜0.05).At 6 months after surgery,the UCVA and BUT of the Ologen collagen matrix implantation group were lower than those of the limbal stem cell transplantation group,and the CA of the Ologen collagen matrix implantation group was higher than that of the limbal stem cell transplantation group,and the differences were statistically significant between the two groups(P＜0.05).At 6 months after surgery,the comfort scores of the limbal stem cell transplantation group were significantly better than those of the Ologen collagen matrix implantation group in four dimensions,including photophobic tears,foreign body sensation,eye pain and hyperemia of the bulbar conjunctiva(P＜0.05).The wound healing time of the limbal stem cell transplantation group was signif-icantly shorter than that of the Ologen collagen matrix implantation group[(2.85±1.06)d vs(3.04±0.31)d;t=2.073,P=0.039].The clinical efficacy rate of the limbal stem cell transplantation group was significantly higher than that of the Ologen collagen matrix implantation group(98.64％vs 93.10％;x2=5.678,P=0.017).The recurrence rate at 6 months after surgery in the limbal stem cell transplantation group was lower than that in the Ologen collagen matrix implantation group(0.00％vs 4.14％;x2=4.325,P=0.038).Conclusion Surgical excision combined with limbal stem cell transplantation is superior to surgical excision combined with Ologen collagen matrix implantation in treatment of pterygium,and surgical excision combined with limbal stem cell transplantation is worth recommending.
Keywords：Ologen collagen matrixLimbal stem cell transplantationPterygiumRefractive statusPterygium excision
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1026-1031 )