Effects of iron overload on T lymphocyte subsets and survival prognosis in patients with newly diagnosed myelodysplastic syndrome
DUAN Lixiang
YU Wenjun
LI Liang
JIAO Xiaolin
ZHAO Dan
MA Yaofang
TAO Yongming
Abstract：Objective To explore the effects of iron overload on T lymphocyte subsets and survival prognosis in patients with newly diagnosed myelodysplastic syndrome(MDS).Methods The clinical data of 58 patients with MDS who were admitted to Yuncheng Central Hospital Affiliated to Shanxi Medical University from January 2018 to December 2023 were retrospectively analyzed,and the study subjects were divided into iron overload group[serum ferritin(SF)1 000 ng/mL,27 cases]and non-iron overload group(SF＜1 000 ng/mL,31 cases)according to their SF levels.The general clinical data,lymphocyte subsets and survival prognosis were compared between the two groups.Results The levels of SF and transferrin saturation in the iron overload group were higher than those in the non-iron overload group,and the levels of peripheral blood CD3+T lymphocytes,CD4+T lymphocytes and CD8+T lymphocytes in the iron overload group were lower than those in the non-iron overload group,and the differences were statistically significant(P＜0.05).The median survival time was 8 months in the iron overload group and 30 months in the non-iron overload group.The overall survival time of the non-iron overload group was significantly better than that of the iron overload group(log-rank test:x2=5.368,P=0.020).The results of multivariate Cox regression analysis showed that iron overload[HR(95％CI)=3.50(1.46-8.39),P=0.005]and the Revised International Prognostic Scoring System(IPSS-R)risk classification at very high risk[HR(95％CI)=6.28(1.15-34.27),P=0.034]were independent risk factors affecting the survival prognosis of the patients with MDS(P＜0.05).Conclusion Iron overload is a risk factor for poor survival prognosis in MDS patients,and iron overload can affect the level of T lymphocyte subsets,which deserves the attention of clinicians.
Keywords：Iron overloadSerum ferritinMyelodysplastic syndromeT lymphocyte subsetsSurvival prognosis
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1009-1013 )