Analysis on the short-term efficacy of lymphoplasmapheresis in treatment of 6 cases of severely active systemic lupus erythematosus complicated with infections in children
LU Fuqing
SONG Kunling
MO Zhuning
WEI Jinshuang
LU Yuanfeeng
WEN Zhihong
LI Hailan
DAI Yan
Abstract：Objective To analyze the short-term efficacy of lymphoplasmapheresis(LPE)in treatment of 6 cases of severely active systemic lupus erythematosus(SLE)complicated with infections in children.Methods The clinical data of 6 pediatric patients with severely active SLE complicated with infections who were treated in the People's Hospital of Guangxi Zhuang Autonomous Region from January 2021 to January 2024 were analyzed.On the basis of traditional drug therapy,the 6 pediatric patients were treated with LPE,and their clinical therapeutic effect and the occurrence of adverse reactions were observed.Results Compared with those before LPE treatment,peripheral blood leukocyte count and lymphocyte count did not change much,and platelet count,B cell count,natural killer(NK)cell count,anti-double-stranded deoxyribonucleic acid(DNA)antibodies level,anti-nuclear antibodies titer and immunoglobulin G(IgG)level,24-hour urine protein quantitation and urinary red blood cell count all decreased to varying degrees,and the complement C3 increased significantly in the 6 pediatric patients after LPE treatment,and the content of hemoglobin decreased in 5 cases but increased in 1 case.No aggravation of vital organ involvement was observed in all the 6 pediatric patients,and all the affected organs gradually improved during the subsequent treatment.No adverse reactions occurred in all the 6 pediatric patients during LPE treatment.Conclusion On the basis of traditional drug therapy,LPE treatment can obtain good clinical effect on severely active SLE complicated with infections in children in a short time.
Keywords：Lymphoplasmapheresis(LPE)Systemic lupus erythematosus(SLE)ChildrenShort-term efficacy
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 988-991 )