Recognizing pediatric type Ⅰ interferonopathy in children—early identification,precision treatment and improved prognosis
GAO Fengqiao
LI Caifeng
Abstract：Type Ⅰ interferonopathy is a type of autoinflammatory diseases caused by single gene mutation,characterized by abnormal activation of type Ⅰ interferon signaling pathway,leading to widespread systemic inflammatory response.In the daily diagnosis and treatment of autoimmune diseases,early identification of type Ⅰ interferonopathy is crucially important.For the patients with onset of diseases at a young age and presented with multi-system inflammatory manifestations and positive autoantibodies,clinicians should be highly vigilant about type Ⅰ interferonopathy and perform genetic testing for early diagnosis if necessary.Early diagnosis and precision treatment not only help to control inflammation in time,but also effectively prevent or slow down the progression of organ injury,and significantly improve the long-term prognosis of the patients.
Keywords：Type Ⅰ interferonopathyChildrenGene mutationDiagnosisTargeted treatmentAutoinflammatory diseases
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 955-960 )