A study on the application value of a novel indicator of HROX index in early diagnosis and treatment of severe pneumonia in children
YAN Qiuli
ZHANG Fangyuan
CHEN Yingqing
SHI Jinjin
NIU Wensi
Abstract：Objective To explore the application value of a novel indicator of HROX index in early diagnosis and treatment of severe pneumonia in children.Methods The clinical data of 198 pediatric patients with pneumonia who were admitted to Suzhou Wujiang District Children's Hospital from February 2020 to December 2022 were retro-spectively collected,including 98 cases of severe pneumonia(severe pneumonia group)and 100 cases of common pneu-monia(common pneumonia group).The general clinical data,laboratory indicators,imaging indicators and HROX index[HROX index=heart rate x respiratory rate/oxygen saturation(SpO2)]were compared between the two groups.The efficacy of HROX index in early diagnosis of severe pneumonia in children and in predicting the need for oxygen therapy in pediatric patients during hospitalization was analyzed.Results Compared with the common pneumonia group,the severe pneumonia group had higher incidence rates of shortness of breath,wheezing,inspiratory three-concave sign and pleural effusion,and longer hospital stay,higher levels of C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),lactate dehydrogenase(LDH),D-dimer and HROX index,and lower levels of neutrophil percentage(NEU)and hemo-globin(Hb),and the differences were statistically significant(P＜0.05).The results of multivariate logistic regression analysis showed that higher HROX index[OR(95％CI)=1.211(1.038-1.414)]and PCT[OR(95％CI)=1.570(1.142-2.157)],IL-6[OR(95％CI)=1.028(1.001-1.057)]and D-dimer[OR(95％CI)=18.697(1.091-320.405)]levels were independent risk factors for promoting the occurrence of severe pneumonia(P＜0.05).The results of receiver operating characteristic(ROC)curve analysis showed that HROX index was helpful for early diagnosis of severe pneu-monia[AUC(95％CI)=0.907(0.863-0.951),P＜0.001],and could predict the need for oxygen therapy during hospitalization in the pediatric patients[AUC(95％CI)=0.902(0.857-0.947),P=0.003].Conclusion HROX index helps clinicians diagnose severe pneumonia early and predicts the need for oxygen therapy during hospitalization in pediatric patients.
Keywords：ChildrenSevere pneumoniaOxygen saturationNovel indicatorEarly diagnosisOxygen therapy
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 881-885 )