The predictive value of peripheral blood CD4+CD25+and CD8+CD28+regulatory T cell levels for the prog-nosis of early cervical cancer patients after laparoscopic radical resection
ZENG Hairong
HUANG Dan
ZHANG Jianjun
HUA Haiqin
Abstract：Objective To analyze the predictive value of peripheral blood CD4+CD25+and CD8+CD28+regu-latory T cell levels for the prognosis of early cervical cancer(CC)patients after laparoscopic radical resection.Methods A total of 204 patients with early CC who underwent laparoscopic radical resection in Danzhou People's Hospital from September 2018 to September 2020 were enrolled.According to the prognosis of the patients during postoperative follow-up period,they were divided into poor prognosis group(43 cases)and good prognosis group(161 cases).The clinical data were compared between the two groups.Spearman rank correlation was used to analyze the correlation between peripheral blood CD4+CD25+regulatory T cell levels and CD8+CD28+regulatory T cell levels.Multivariate logistic regression was used to analyze the influencing factors of poor prognosis in patients with early CC after laparoscopic radical resection.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of peripheral blood CD4+CD25+and CD8+CD28+regulatory T cell levels for the poor prognosis of early CC patients after laparoscopic radical resection.Results The CD4+CD25+regulatory T cells,carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)levels,the proportion of positive postoperative margin and the proportion of intraoperative parametrial infiltration in the poor prognosis group were higher than those in the good prognosis group.The CD8+CD28+regulatory T cell levels in the poor prognosis group were lower than those in the good prognosis group,and the differences were statistically sig-nificant(P＜0.05).The results of Spearman rank correlation analysis showed that there was a negative correlation between peripheral blood CD4+CD25+regulatory T cell levels and CD8+CD28+regulatory T cell levels in early CC patients(rs=-0.478,P＜0.05).The results of multivariate logistic regression analysis showed that higher CEA,CA125 and CD4+CD25+regulatory T cell levels were independent risk factors for promoting the occurrence of poor prognosis in the early CC patients after laparoscopic radical resection(P＜0.05),and higher CD8+CD28+regulatory T cell levels were independent protective factors for inhibiting the occurrence of poor prognosis in early CC patients after laparoscopic radical resection(P＜0.05).The results of ROC curve analysis showed that peripheral blood CD4+CD25+and CD8+CD28+regulatory T cell levels could effectively predict poor prognosis of early CC patients after laparoscopic radical resection(P＜0.05).The combination of the two indicators could further improve the predictive efficacy[AUC(95％CI)=0.939(0.898-0.979),P＜0.001],with sensitivity and specificity being 86.00％and 88.20％,respectively.Conclusion Peripheral blood CD4+CD25+and CD8+CD28+regulatory T cell levels are related to the poor prognosis of early CC patients after lap-aroscopic radical resection,and both indicators can effectively predict the poor prognosis of early CC patients after laparoscopic radical resection.
Keywords：Cervical cancer(CC)Laparoscopic radical resectionCD4+CD25+regulatory T cellCD8+CD28+regulatory T cellPrognosis
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 800-805 )