Effects of reproductive tract infections on the expressions of MMP-2 and MMP-9 in cervical secretions and the adverse maternal-infant outcomes in pregnant women with term premature rupture of membrane and in pregnant women with preterm premature rupture of membrane
LI Jie
CHENG Mumo
CHEN Lingling
XIE Zonglin
YAN Xinyu
ZHANG Zhijun
Abstract：Objective To analyze the effects of reproductive tract infections on the expressions of matrix met-alloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)and the adverse maternal-infant outcomes in pregnant women with term premature rupture of membrane(tPROM)and in pregnant women with preterm premature rupture of membrane(pPROM).Methods A total of 110 pregnant women with premature rupture of membrane(PROM)who saw a doctor in Taihe Hospital,Hubei University of Medicine from June 2021 to June 2023 were recruited as the study subjects.According to the situation of reproductive tract infections and gestational weeks,the patients were divided into pPROM infection group(34 cases),pPROM non-infection group(26 cases),tPROM infection group(34 cases)and tPROM non-infection group(16 cases).The general data,the levels of MMP-2 and MMP-9 expressions in cervical secretions,and adverse maternal-infant outcomes were compared among the four groups.Multivariate logistic regression was used to analyse the influencing factors of adverse maternal-infant outcomes in the PROM pregnant women.Results There were no significant differences in age,gravidity,body mass index,smoking history and alcohol drinking history among the four groups(P＞0.05).The levels of MMP-2 and MMP-9 expressions in cervical secretions were significantly different among the four groups(P＜0.05),and the levels of MMP-2 and MMP-9 expressions in cervical secretions in the pPROM infection group were higher than those in the pPROM non-infection group and the tPROM non-infection group,and the levels of MMP-2 and MMP-9 expressions in cervical secretions in the tPROM infection group were higher than those in the tPROM non-infection group,and the differences were statistically significant(P＜0.05).The overall incidence rates of chorioamnionitis and adverse maternal-infant outcomes were significantly different among the four groups(P＜0.05),and the incidence rate of chorioamnionitis in the pPROM infection group was higher than that in the tPROM infection group and the tPROM non-infection group,and the overall incidence rate of adverse maternal-infant outcomes in the pPROM infection group was higher than that in the pPROM non-infection group and the tPROM non-infection group,and the differences were statistically significant(P＜0.05).The results of multivariate logistic regression analysis showed that reproductive tract infections and higher levels of MMP-2 and MMP-9 expressions in cervical secretions were inde-pendent risk factors of adverse maternal-infant outcomes in the PROM pregnant women(P＜0.05).Conclusion Repro-ductive tract infections can increase the levels of MMP-2 and MMP-9 expressions in cervical secretions of pregnant women with tPROM and in cervical secretions of pregnant women with pPROM.Reproductive tract infections and higher levels of MMP-2 and MMP-9 expressions in cervical secretions are independent risk factors of adverse maternal-infant outcomes in PROM pregnant women.
Keywords：Reproductive tract infectionTerm premature rupture of membrane(tPROM)Preterm pre-mature rupture of membrane(pPROM)Matrix metalloproteinase-2(MMP-2)Matrix metalloproteinase-9(MMP-9)Adverse maternal-infant outcome
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 778-782 )