Expressions of mismatch repair proteins in 3 188 cases of colorectal cancer in south China area and their clini-copathological features
FU Qiaoyu
JIN Tian'en
JIANG Hanwen
HONG Juan
FANG Chutian
CHEN Zhongsheng
Abstract：Objective To explore the expressions of mismatch repair(MMR)proteins in colorectal cancer tissues in south China area and their clinicopathological features.Methods A total of 3 188 cases of colorectal cancer archived at Guangzhou Da'an Clinical Laboratory Center from January 2019 to December 2023 were collected.Immunohistochemical method was used to detect the expressions of MLH1,PMS2,MSH2 and MSH6 proteins in colorectal cancer tissues,and the relationship between these protein expressions and clinicopathological features was further analyzed.Results Among the 3 188 cases of colorectal cancer,254 cases(with a deficiency rate of 8.0％)were found to have mismatch repair protein deficiency(MMRd),and there were 146 cases of MLH1-/PMS2-,accounting for 57.5％of MMRd,and there were 35 cases of MSH2-/MSH6-,accounting for 13.8％of MMRd.There were significant differences in the incidence rates of MMRd between different ages,between tumor locations and between differentiation levels(P＜0.05).Among the 3 188 cases of colorectal cancer,the analysis of specimens of 646 cases receiving radical resection for colorectal cancer revealed that MMRd was closely related to tumor maximum diameter,lymph node metastasis,vascular invasion,nerve invasion and cancer nodules(P＜0.05).Conclusion The incidence rate of MMRd in colorectal cancer in south China area is 8.0％,and MMRd is more common in young women and their tumor sites are more common in ileocecum and ascending colon and these MMRd tumors are often poorly differentiated.MMRd tumors are often characterized by large tumor diameters(≥5 cm),rare lymph node metastasis,rare cancer nodules,no vascular invasion and no nerve invasion.
Keywords：Colorectal cancerMismatch repair proteinMicrosatellite instabilityImmunohistochemistrySouthern China
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 753-758 )