Clinicopathological observation on clear cell renal cell carcinoma metastasizing to the lung
ZHANG Junlin
CUI Feng
HAN Silu
WANG Xinyi
LIN Xiaoting
MEI Kaiyong
Abstract：Objective To explore the clinicopathological features of clear cell renal cell carcinoma metastasizing to the lung.Methods The clinicopathological features of 4 cases of clear cell renal cell carcinoma metastasizing to the lung which was diagnosed by puncture biopsy were retrospectively analyzed.CK,p40,p63,TTF-1,Napsin A,PAX8 and CD10 were detected by using immunohistochemical staining method,and their expressions were observed.Results Among the 4 patients with clear cell renal cell carcinoma metastasizing to the lung,there were 3 males and 1 female,aged 44-71 years,with an average age of 58.75 years.All the 4 cases had multiple nodules in both lungs,with the largest nodule of each case located in the left lower lobe of the lung in 2 cases and the right lower lobe of the lung in 2 cases.All the 4 cases were positive for CK,PAX8,and CD10 expressions,while negative for TTF-1,Napsin A,p40 and p63 expressions.Conclusion Lung tumors characterized by clear cell morphology need to be considered for the possibility of clear cell renal cell carcinoma metastasizing to the lung.
Keywords：LungRenal cell carcinomaClear cellMetastasisPathology
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 749-752 )