A study on the clinicopathological features of 5 cases of ALK-positive histiocytosis
ZENG Ziqi
WANG Yu
CUI Feng
YANG Jie
Abstract：Objective To explore the clinicopathological features of anaplastic lymphoma kinase(ALK)-positive histiocytosis patients.Methods The clinical medical record data of 5 ALK-positive histiocytosis patients and their patho-logical tissues were collected.All the tissues were performed conventional hematoxylin-eosin staining to observe the his-topathological features.EnVision immunohistochemistry method was used to detect the expression of ALK protein,and fluorescence in situ hybridization(FISH)method and next-generation sequencing(NGS)method were used to detect the genetic mutation situation of the ALK gene.Results Among the 5 cases,3 cases were adults and 2 cases were children,and 4 cases were female and 1 case was male.Among the 5 cases,the tumor cells of 1 case were spindle cell-like,and the tumor cells of 1 case were foam-like histiocytoid,and the tumor cells of the other 3 cases were epithelioid and his-tiocytoid.The histiocyte markers of CD163 and CD68,and ALK protein were strongly expressed in all the cases.All the 5 cases had ALK gene translocations,which were KIF5B-ALK fusion gene.Conclusion In this study,the histological morphological pedigree of 5 cases of ALK-positive histiocytosis includes epithelioid,foam-like histocytes and spindle cell morphology,all of which strongly express the histiocyte markers of CD163 and CD68,and ALK protein,and the chromosome breakages in ALK gene are detected in all the cases,and all of them are KIF5B-ALK fusion gene.
Keywords：ALK geneALK-positive histiocytosisALK gene rearrangement-related tumor
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 740-744 )