Analysis on the clinicopathological features of 25 cases of metastatic carcinoma in the digestive tract

MA Yihui; LI Jiajing; WANG Feng; WANG Zhengyang; HUANG Pei; LI Chenfei; LI Wencai

doi:10.3969/j.issn.1674-3806.2024.07.03

Abstract：Objective To explore the clinicopathological features of metastatic carcinoma in the digestive tract,and to provide experience for early detection and diagnosis of metastatic carcinoma in the digestive tract in patients with malignant tumors.Methods The clinicopathological data of 25 patients with pathological diagnosis of metastatic carcinoma in the digestive tract in the First Affiliated Hospital of Zhengzhou University from January 2011 to December 2021 were retrospectively collected for inductive description and analysis.Results Among the 25 cases with metastatic carcinoma in the digestive tract,there were 11 cases of lung cancer,8 cases of breast cancer,4 cases of kidney cancer and 2 cases of urothelial cancer.Among the 25 cases with metastatic carcinoma in the digestive tract,14 cases were male and 11 cases were female.The patients ranged in age from 28 to 73 years,with a mean age of 55.6 years.The mean age of the patients was 57.9 years at the time when metastatic carcinoma in the digestive tract was definitely diagnosed.The average interval between the time of diagnosis of primary carcinoma and the time of diagnosis of metastatic carcinoma in the digestive tract was 36 months.Among the 25 cases with metastatic carcinoma in the digestive tract,9 cases had metastatic car-cinoma in the upper digestive tract and 16 cases had metastatic carcinoma in the lower digestive tract.At the time of definite diagnosis of metastatic carcinoma in the digestive tract,15 cases had metastases in other organs,and the other 10 cases had lymph node metastases in multiple sites in the whole body.Under the microscope,the mucosal surface was mostly intact,and the transition between tumor tissues and their surrounding mucosa was abrupt,and vascular cancer thrombi were easily seen.Metastatic lung adenocarcinoma was mostly solid and flaky growth,while breast cancer was mostly poorly differentiated and cord-like infiltrating growth.Metastatic carcinoma could express relevant immunohis-tochemical markers with good specificity.Conclusion The occurrence of metastatic carcinoma in the digestive tract often indicates a late stage event in its progression.When malignant epithelial tumors of the digestive tract with unique mor-phology are observed,the possibility of metastatic carcinoma should be considered.The patients'medical history is paid attention to and immunohistochemical detection is reasonably chosen to avoid missed diagnosis and misdiagnosis.