Analysis on the effects and treatment costs of different progesterone administration regimens on patients under-going preimplantation genetic testing for frozen-thawed embryo transfer
HE Chenhui
ZHAO Lei
ZHAO Yu
LIU Qianru
Abstract：Objective To analyze the effects and treatment costs of different progesterone administration regi-mens on patients undergoing preimplantation genetic testing for frozen-thawed embryo transfer(PGT-FET).Methods The clinical data of 169 infertile patients who underwent PGT-FET in the Reproductive Medicine Center of Taihe Hospital,Shiyan City from August 2020 to July 2022 were retrospectively analyzed.According to the progesterone administration regimens adopted by the patients,the patients were divided into group A(oral administration of progesterone capsules,82 cases)and group B(vaginal administration of progesterone softgel capsules,87 cases).The hormonal indicators and oocyte harvest on the day of injection of human chorionic gonadotropin(HCG),endometrial thickness and receptivity indicators[resistance index(RI),pulse index(PI)and peak systolic velocity/end diastolic velocity(S/D)]on the day of injection of HCG and on the day of embryo transfer,embryo transfer,pregnancy outcomes,vaginal bleeding and cost-effectiveness ratio were compared between the two groups.Results There were no significant differences between the two groups in luteinizing hormone(LH)on the clay of injection of HCG,estradiol(E2)on the clay of injection of HCG,progesterone(P)on the day of injection of HCG,number of oocyte harvest,number of M Ⅱ oocytes,and endometrial thickness and uterine artery S/D,RI,PI on the day of injection of HCG and on the day of embryo transfer,the number of transferred blastocysts,the rate of high-quality transferred blastocysts,biochemical pregnancy rate,clinical pregnancy rate,first trimester abortion rate and continue pregnancy rate(P＞0.05).The rate of early vaginal bleeding and the rate of late vaginal bleeding in the group A were significantly lower than those in the group B(P＜0.05).The cost-effectiveness ratio of the group A(6.72)was lower than that of the group B(8.41).Conclusion In PGT-FET patients,the clinical effect of oral administration of progesterone capsules and the protective effect of oral administration of progesterone cap-sules on endometrial receptivity are similar to those of vaginal administration of progesterone softgel capsules,but the former treatment can reduce the rate of vaginal bleeding and treatment costs.
Keywords：Frozen-thawed embryo transferPreimplantation genetic testingProgesteronePregnancy outcomeTreatment costs
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 651-655 )