Advances in the regulatory effect of hypoxia-inducible factor-1α on energy metabolism of macrophages during Mycobacterium tuberculosis infection
LI Chaowei
XU Junfa
ZHENG Biying
Abstract：Macrophages,as an important component of the body's immune system,directly affect the host's ability to clear Mycobacterium tuberculosis(Mtb)through energy metabolism.Hypoxia-inducible factor-1α(HIF-1α)regulates the immune response to Mtb by influencing the energy metabolism pathway in macrophages,and plays an important role in the anti-tuberculosis immunity of macrophages.This paper reviews advances in the regulatory effect of HIF-1αon energy metabolism of macrophages during Mtb infection.
Keywords：Mycobacterium tuberculosis(Mtb)Hypoxia-inducible factor-1 α(HIF-1α)MacrophageEnergy metabolismSignaling pathwayTherapeutic target
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 581-584 )