Analysis on the clinical CT imaging and pathological features of 7 cases of lymphocytic interstitial pneumonia
LIU Siqiu
YANG Xinguan
JIANG Chunrong
Abstract：Objective To analyze the clinical,CT imaging and pathological features of 7 cases of lymphocytic interstitial pneumonia(LIP).Methods The clinical and imaging data of 7 cases of LIP proved pathologically were ret-rospectively analyzed.All the cases underwent chest thin-section CT examination.Results All the 7 LIP patients were female,among whom,4 cases had the manifestation of diffuse patchy ground-glass opacities on their CT images.Among the 4 cases of diffuse patchy ground-glass opacities,3 cases accompanied with grids and small nodules.Among the 7 LIP patients,3 cases had the manifestation of focally distributed patchy ground-glass opacities.Among the 3 cases of focally distributed patchy ground-glass opacities,1 case showed locally mixed small nodules.Among the 7 LIP patients,5 cases had multiple thin-walled pulmonary cysts containing air,4 cases accompanied with mediastinal lymph node enlargement.Hematoxylin and eosin(HE)staining of pathological biopsy tissues mainly showed diffuse lymphocyte infiltration in lung interstitium,and the immunohistochemical staining mainly indicated the increase of CD3 cells and polyclonal CD20 cells.Conclusion LIP is a rare disease,which tends to occur in female patients with Sjögren's syndrome.When the lungs show patchy ground-glass opacities and changes in multiple thin-walled pulmonary cysts containing air on chest high-resolution CT,and when the pathological manifestation is diffuse lymphocyte infiltration in the lung interstitium,LIP is highly suggested.
Keywords：Lymphocytic interstitial pneumonia(LIP)Lung diseasesInterstitial fibrosis
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 562-565 )