A Meta-analysis of the efficacy and safety of platelet-rich plasma in treatment of alopecia areata
JIANG Yuwei
LIANG Wen
FANG Qiang
LIAO Haiquan
YANG Bin
Abstract：Objective To systematically evaluate the clinical efficacy and safety of platelet-rich plasma(PRP)in treatment of alopecia areata(AA).Methods China National Knowledge Infrastructure(CNKI),Wanfang medical online,VIP network,Sinomed database,PubMed database,EMBASE database,Cochrane Library database and Web of Science database were searched.During the period from the establishment of the databases to April 2023,the papers were searched and the relevant clinical studies on the treatment of AA with PRP were included,and the evaluation indicators included study indicators involving the Severity of Alopecia Tool(SALT)score or the SALT 6-point score.The efficacy and safety of PRP in treatment of AA were systematically evaluated.Results A total of 7 studies were included for Meta-analysis.After PRP treatment,the SALT score of the patients decreased significantly(P＜0.05).SALT score decreased in both PRP treatment group and steroid treatment group,but there was no statistically significant difference in the SALT score between the two groups[SMD(95％CI)=-0.41(-1.22-0.40),I2=81.00％,P=0.33].Five studies had men-tioned the occurrence of adverse reactions during the treatment of AA with PRP.These adverse reactions were mainly manifested as transient injection site pain,local erythema,burning sensation and edema,which could be recovered within a short time,and AA patients were generally well tolerated for PRP treatment.Conclusion PRP is safe and effective in treating AA.
Keywords：Platelet-rich plasma(PRP)Alopecia areata(AA)Meta-analysis
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 548-553 )