A study on the relationship between double-negative T cells ratio in peripheral blood and prognosis of advanced rectal cancer after neoadjuvant therapy
ZHAO Xinxuan
GUO Yuting
ZHANG Yixun
WEI Qiang
LIU Haiyi
Abstract：Objective To explore the relationship between double-negative T cells(DNT)ratio in peripheral blood and prognosis of advanced rectal cancer after neoadjuvant therapy.Methods The clinical data of 219 patients with rectal cancer who were admitted to the Department of Colorectal Surgery of Shanxi Cancer Hospital from January 2017 to December 2021 were retrospectively collected.The indicator of DNT ratio of the patients after neoadjuvant therapy was collected,and the median value was taken as the cut-off value,and the patients were divided into high level DNT group(DNT≥3％,125 cases)and low level DNT group(DNT＜3％,94 cases).The indicators of TNM stage,patho-logical tumor regression grade(TRG),neurovascular invasion and survival prognosis were compared between the two groups.Results There were no significant differences in gender,age,body mass index,distance from tumor lower bound to the anus,preoperative tumor stage(cT stage,cN stage),and perirectal fascia invasion between the two groups(P＞0.05).Compared with the patients in the high level DNT group,the patients in the low level DNT group had lower rate of neurovascular invasion(P=0.014),and better survival prognosis(P=0.014).Conclusion After neoadjuvant therapy,DNT ratio in peripheral blood is significantly correlated with neurovascular invasion and survival prognosis of the patients with rectal cancer.The patients in the low level DNT group have a lower rate of neurovascular invasion and a longer overall survival period.
Keywords：Rectal cancerNeoadjuvant therapyDouble-negative T cells(DNT)Prognosis
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 501-505 )