Effects of etomidate and ciprofol on ventricular-arterial coupling in elderly hypertension patients during induction of general anesthesia
HUANG Jingxiang
CAO Yang
PENG Weilong
LUO Jianhua
Abstract：Objective To analyze the effects of etomidate and ciprofol on ventricular-arterial coupling(VAC)in elderly hypertension patients during induction of general anesthesia.Methods A total of 57 elderly hypertension patients who underwent surgical treatment under general anesthesia in Guangzhou Red Cross Hospital from May 2023 to November 2023 were recruited and divided into etomidate group(group E,28 cases)and ciprofol group(group C,29 cases)by random number table method.Mean arterial pressure(MAP),heart rate(HR),left ventricle stroke volume(LVSV),effective arterial elastance(Ea),left ventricle end-systolic elastance(Ees)and Ea to Ees ratio(Ea/Ees)were recorded in the two groups before anesthesia induction(T0),1 minute after anesthesia induction(T1),2 minutes after anesthesia induction(T2),before tracheal intubation(T3)and 1 minute after completion of tracheal intubation(T4).The post-operative extubation time,length of stay at post-anesthesia care unit(PACU),incidence of adverse reactions,use of atropine and phenylephrine and the number of patients with Ea/Ees＞1.0 were recorded in the two groups.Results Compared with those at T0,Ea/Ees increased at T,-T3,and MAP,HR and LVSV decreased at T1-T3,and HR increased at T4,and Ea increased at T1 and T2,and Ees decreased at T2-T4 in the group E.Compared with those at T0,Ea/Ees increased at T,-T4,and MAP,HR,LVSV and Ees decreased at T,-T4,and Ea increased at T1-T3 and decreased at T4 in the group C,and the differences were statistically significant(P＜0.05).Compared with the group C,the group E had high HR and LVSV at T1-T4,low Ea/Ees at T1-T4,high MAP at T3 and T4,high Ees at T1,T3 and T4,and low Ea at T2,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in the postoperative extubation time,length of stay at PACU,incidence of adverse reactions,use of atropine and pheny-lephrine and the proportion of patients with Ea/Ees＞1.0 between the two groups(P＞0.05).Conclusion Both eto-midate and ciprofol have good safety in the induction of anesthesia in elderly patients with hypertension,but etomidate can better maintain the VAC.
Keywords：Ventricular-arterial couplingEffective arterial elastanceLeft ventricle end-systolic elastanceEtomidateCiprofol
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 442-447 )