Observation on the clinical efficacy of repetitive transcranial magnetic stimulation combined with citalopram hydrobromide in treatment of post-stroke sleep disorder

LI Jingyan; ZHANG Ping

doi:10.3969/j.issn.1674-3806.2024.04.15

Abstract：Objective To observe the clinical efficacy of repetitive transcranial magnetic stimulation(rTMS)combined with citalopram hydrobromide in treatment of post-stroke sleep disorder(PSSD).Methods The clinical data of 94 patients with PSSD who were treated in the First Affiliated Hospital of Xinxiang Medical University from April 2021 to January 2023 were retrospectively analyzed.The patients were divided into control group and combination group according to different treatment plans,with 47 cases in each group.The control group was treated with citalopram hydrobromide and the combination group was treated with rTMS combined with citalopram hydrobromide,and both groups were treated contin-uously for 8 weeks.The total effective rate,sleep quality at different time points,negative emotion,motor threshold(MT)and the levels of inflammatory factors were compared between the two groups.Results The total effective rate after treatment in the combination group was significantly higher than that in the control group(95.74％vs 78.72％;x2=6.114,P=0.013).After treatment,the Pittsburgh Sleep Quality Index(PSQI),Insomnia Severity Index(ISI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and the levels of interleukin(IL)-6,tumor necrosis factor-α(TNF-α)and IL-2 showed a downward trend while MT showed an increasing trend,and the differences were statistically significant(P＜0.05).After 4 and 8 weeks of treatment,the PSQI,ISI,BDI and BAI scores as well as the levels of IL-6,TNF-α and IL-2 in the combination group were lower than those in the control group,and MT in the combination group was higher than that in the control group,and the differences were statistically significant(P＜0.05).Conclusion The combi-nation of rTMS and citalopram hydrobromide is significantly effective in the treatment of PSSD patients,which can reduce inflammation,increase MT,and improve sleep disorder and negative emotion.