Research progress on the therapeutic potential effects of human bone marrow mesenchymal stem cells and their exosomes in the treatment of hepatic ischemia-reperfusion injury after liver transplantation
ZHANG Yihan
YAO Weifeng
Abstract：Hepatic ischemia-reperfusion injury(HIRI)is an inevitable pathophysiological process during tra-ditional liver transplantation.Its severity can be affected by multiple factors involving both donors and recipients,and the most severe consequence can be early post-operative graft dysfunction.Human bone marrow mesenchymal stem cells(BMSCs)and their exosomes have been proven to be capable of promoting tissue regeneration and immune mod-ulation in clinical trials,therefore,they have promising prospects in treating and preventing HIRI.We aim to review the current research progress in the potential mechanism as well as the future research direction of BMSCs and their exosomes in the prevention and treatment of HIRI.
Keywords：Hepatic ischemia-reperfusion injury(HIRI)Liver transplantationHuman bone marrow mesenchymal stem cells(BMSCs)Exosome
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 384-388 )