An exploration on effects of different surgical approaches on levels of postoperative circulating tumor cells in patients with early papillary thyroid carcinoma
WANG Huiling
PAN Xiaoming
LYU Mian
HUANG Yonghong
XU Changqiang
Abstract：Objective To explore the effects of different surgical approaches on levels of postoperative circu-lating tumor cells(CTCs)in patients with early papillary thyroid carcinoma(PTC).Methods The clinical data of 109 patients with early PTC who were admitted to the Second Nanning People's Hospital from December 2017 to March 2022 were retrospectively analyzed.Among them,78 patients underwent traditional open surgery(group A),and 14 patients(group B)underwent endoscopic thyroidectomy via axillary approach,and 17 patients(group C)underwent endo-scopic thyroidectomy via submental vestibular approach.The differences in perioperative indicators,postoperative hospi-tal stay,and postoperative CTCs types and levels were compared among the three groups.Results The intraoperative bleeding volume and the number of lymph nodes dissected in group A were greater than those in group B and group C,and the postoperative extubation time and the duration of postoperative hospital stay in group A were longer than those in group C,and the differences were statistically significant(P＜0.05).The postoperative extubation time in group B was significantly longer than that in group C(P＜0.05).There was no significant difference in the operation time among the three groups(P＞0.05).There was no significant difference in the positive rate of CTCs among the three groups(P＞0.05).There were significant differences in total CTCs count and mixed CTCs count among the three groups(P＜0.05),a-mong which group C had the highest levels of postoperative counts.Conclusion The three surgical approaches have good efficacy and safety for early PTC.Different approaches have a certain effect on the level of postoperative CTCs,but the effects of these differences on the prognosis of the patients still need to be further verified.
Keywords：Papillary thyroid carcinoma(PTC)Traditional open surgeryEndoscopic surgery via axillary approachEndoscopic surgery via submental vestibular approachCirculating tumor cells(CTCs)
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 333-337 )