An exploration of the effect of gestational diabetes mellitus on neonatal left ventricular function
LU Anfeng
LIANG Meixin
HUANG Peilu
BI Lei
HUANG Guosheng
HUANG Haiyan
Abstract：Objective To explore the effect of gestational diabetes mellitus(GDM)on neonatal left ventricular function.Methods Ninety-eight full-term neonates delivered by gestational diabetes mellitus(GDM)mothers who were admitted to the Department of Neonatology of Qinzhou Maternal and Child Health Care Hospital from January 2022 to July 2022 were selected as the GDM group.According to the blood glucose control levels of the mothers during pregnancy,the patients in the GDM group were further divided into the blood glucose control meeting standards group(63 cases)and the blood glucose control failing to meet standards group(35 cases).Three hundred and eighty-three full-term neonates delivered by mothers without GDM who were admitted to the same hospital during the same period were selected as the control group.The serum myocardial enzyme profile,septal thickness and systolic peak strain level of each ventricular septal segment(basal ventricular septum,medial ventricular septum and apical ventricular septum)were compared between the neonates in the two groups.Results There were no significant differences in neonatal lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase lsoenzyme-MB(CK-MB)and cardiac troponin I(cTnI)between the GDM group and the control group(P＞0.05).Compared with those in the control group,the thickness of the neonatal ventricular septum increased,and the septal strain of basal,middle and apical segments were lower in the GDM group,and the differences were statistically significant(P＜0.05).Compared with those in the blood glucose control meeting standards group,the thickness of the neonatal ventricular septum increased,and the septal strain of basal,middle and apical segments were lower than those in the blood glucose control failing to meet standards group,and the differences were statistically significant(P＜0.05).Conclusion The ventricular septa of the neonates delivered by the mothers with GDM are thicker than those of the normal full-term neonates,and these neonates delivered by the GDM mothers have myocardial mechanical changes in their left ventricles,and the changes are more obvious in the neonates delivered by the GDM mothers with blood glucose control failing to meet standards.Clinicians should pay more attention to the perinatal health care of the mothers with GDM to help them control blood glucose level.
Keywords：Gestational diabetes mellitus(GDM)Left ventricular functionNeonatePerinatal health care
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 323-327 )