A study on the relationship between serum uric acid levels and patch OCT characteristics of culprit vessels in patients with acute coronary syndrome

SU Xiutian; LIU Weifeng; WANG Hua; REN Mengmeng; YU Liangliang; ZHONG Lin

doi:10.3969/j.issn.1674-3806.2024.03.13

Abstract：Objective To explore the relationship between serum uric acid(sUA)levels and patch character-istics of culprit vessels in patients with acute coronary syndrome(ACS).Methods The clinical data of 268 patients with ACS who were admitted to the Department of Cardiovascular Medicine of Yantai Yuhuangding Hospital,Qingdao University from January 2018 to October 2022 were retrospectively analyzed,and the patients were divided into high sUA group(≥6 mg/dL,117 cases)and low sUA group(＜6 mg/dL,151 cases)according to sUA levels.The clinical data as well as coronary artery angiography and optical coherence tomography(OCT)examination data were compared between the two groups.The relationship between sUA levels and patch characteristics of culprit vessels was analyzed by using multivariate regression.Results The body mass index level of the high sUA group was higher than that of the low sUA group,and the proportion of males and patients complicated with hyperlipidemia in the high sUA group was higher than that in the low sUA group,and the patients in the high sUA group were younger than those in the low sUA group,and the differences were statistically significant(P＜0.05).The levels of hemoglobin,creatinine,triglyceride,lipoprotein a and homocysteine in the high sUA group were higher than those in the low sUA group,and the differences were statistically significant(P＜0.05).The rate of collateral circulation formation in the low sUA group was higher than that in the high sUA group,and the difference was statistically significant(P＜0.05).However,there were no statistically significant differences in the other coronary artery angiography indexes between the two groups(P＞0.05).The rate of luminal stenosis,proximal lumen reference area,distal lumen reference area,red thrombosis rate and mac-rophage infiltration rate in the high sUA group were higher than those in the low sUA group,and the differences were statistically significant(P＜0.05).The results of multivariate regression analysis showed that the increase of sUA level was a risk factor for promoting red thrombosis[OR(95%CI)= 1.490(1.071-2.075),P=0.018]and the occurrence of macrophage infiltration[OR(95%CI)= 1.278(1.045-1.563),P=0.017],and was positively correlated with proxi-mal lumen reference area[β(95%CI)= 0.492(0.155-0.828),P=0.004].Conclusion The increase of sUA level is a risk factor for promoting red thrombosis and the occurrence of macrophage infiltration,which deserves the attention of clinicians.