A study on the correlation of changes in serum miR-133a levels with thyroid hormone and lipid metabolism in hyperthyroidism patients
HUANG Baole
WU Feng
YUE Yue
ZHENG Guiling
Abstract：Objective To explore the correlation of changes in serum miR-133a levels with thyroid hormone and lipid metabolism in hyperthyroidism patients.Methods A total of 100 patients with new onset of dominant hyper-thyroidism who were admitted to the 983rd Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from October 2020 to August 2022 were recruited as the hyperthyroidism group,of whom 28 patients received standard methimazole treatment.Other 100 healthy individuals who underwent physical examination during the same period were selected as the control group.The clinical data such as gender,age,thyroid hormone,liver function and biochemical indicators of the research subjects were collected.The serum miR-133a level was detected by using real-time fluorescence quantitative polymerase chain reaction(PCR),and the correlation of serum miR-133a level with thyroid hormone and lipid metabolism levels was analyzed.Results Compared with those in the control group,the levels of free thyroxine(FT4),free triiodothyronine(FT3),thyroid-stimulating hormone receptor antibody(TRAb),diastolic blood pressure,alanine aminotransferase(ALT),total bilirubin(TBIL)and direct bilirubin(DBIL)in the hyperthyroidism group were increased,while the levels of body mass index(BMI),waist circumference,total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and thyroid-stimulating hormone(TSH)in the hyperthyroidism group were decreased,and the differences were statistically significant(P＜0.05).The serum miR-133a level in the hyperthyroidism group was significantly lower than that in the control group(Z=9.796,P＜0.001).In the hyperthyroidism group,the serum miR-133a level was negatively correlated with ALT,FT3 and FT4 levels(P＜0.05),and was positively correlated with TC,LDL-C and TSH levels(P＜0.05).After receiving treatment with methimazole,the hyperthyroidism patients had significantly decreased FT3 and FT4 levels(P＜0.05),and significantly increased TC,LDL-C,TSH and serum miR-133a levels(P＜0.05).The changes in serum miR-133a levels before and after treatment were negatively correlated with the changes in FT3(rs =-0.728,P＜0.001)and FT4 levels(rs =-0.377,P=0.048),but were not significantly correlated with the changes in TC,TG,LDL-C and TSH levels(P＞0.05).Conclusion The serum miR-133a levels in hyperthyroidism patients are down-regulated,which may be related to the lipid metabolism disorders caused by elevated thyroid hor-mone.
Keywords：HyperthyroidismmiR-133aThyroid hormone(TH)Lipid metabolism disorder
Publication Date：2024-03-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 307-311 )